IGF-1 Lr3 (Insulin-like Growth Factor-I Long R3) is an 83 amino acid analog of human IGF-I comprising the complete human IGF-I sequence with the substitution of an Arg for the Glu at position 3 (hence R3), as well as a 13 amino acid extension peptide at the N-terminus.
IGF-I Lr3 is significantly more potent (2-3x) than IGF-I in studies, because it has a lower affinity to be rendered inactive by IGF binding proteins.
IGF-1 builds new muscle tissue by promoting nitrogen retention and protein synthesis. This causes the growth of muscles through both hyperplasia (which is an increase in number of muscle cells) and mitogenesis (which is the actual growth of new muscle fibers). Thus IGF-1 not only makes muscle fibers bigger, it makes more of them as well! IGF-1's effects are not limited to building new muscle, however. It has a potent effect on lipid (fat) metabolism, and helps the body burn fat at a significantly elevated rate. In addition, IGF-1 is both a neuroprotector and neuropromotor, which improves mental functions such as reflexes, memory, and learning ability. IGF is also important for production of connective tissue and insuring proper bone density.
IGF-1Lr3 is basically a polypeptide hormone that has the same some of the same molecular properties as insulin.Ig-f-1 dose actually stand for insulin-like growth factor. IGF-1Lr3 is mainly responsible for long bone growth in children and it also affects muscle growth and repair of adults. IGF-1Lr3 is a more potent version of IGF-1Lr3. It's chemically altered i like to think "enhanced" to prevent deactivation by IGF-1Lr3 binding proteins in the bloodstream. This results in a longer half-life of 20-30 hours instead of 20 min... So that means a far more effective version than the short chain we we re perhaps more familiar with.IGF-1Lr3 is also known as IGF-1Lr3 or Insulin-Like Growth Factor-I Long Arg3.
Why IG-F1 and not GH? Growth hormone actually is a precursor to IG-F1 Growth hormone does not directly cause muscle growth, but indirectly causes muscle growth by signaling the release of IG-F1.Growth Hormone (HG-H) can be very expensive, and to see muscle growth it needs to be paired with insulin or other anabolic steroids. This makes IG-F1 variants like LR3 and DES, which can be used as a standalone drug, a much more viable option for bodybuilder looking to see solid recovery of damaged tissue and muscle growth.